Acute & Chronic Pain

Pain is a major healthcare issue, with high prevalence, significant patient burden and substantial economic impact.

Patients suffering from acute pain, such as post-operative pain, or chronic pain, such as osteoarthritis, may receive opioids or nonsteroidal anti-inflammatory drugs (NSAIDs) for pain.

In the US, nearly one-half of all adults suffered from pain in the past three months, with more than 20 percent of Americans suffering from chronic pain. Chronic pain has a substantial impact on quality of life, negatively impacting patients’ mobility, productivity, and physical and mental health.

The estimated cost of pain in the US ranges from $560-635 billion each year, which is more than the annual cost of heart disease, stroke, and cancer combined. The misuse and addiction to opioids is a serious national crisis that affects public health as well as social and economic welfare. In 2019, nearly 50,000 people in the US died from opioid-involved overdoses.

There is a need for opioid-sparing therapies in postoperative pain due to the significant risks associated with opioids, including respiratory depression, constipation, tolerance and hyperalgesia, and risk of addiction. Current pain therapies are inadequate, and there is a need for more effective and safer treatment options.