Acadia Pharmaceuticals Presents New Dementia-Related Psychosis Real-World Outcomes Data at Psych Congress 2021
– Analyses indicate ongoing need for approved treatments with favorable benefit-risk profile for treating patients with dementia-related hallucinations and delusions
“The suboptimal outcomes and costs associated with off-label use of dopaminergic atypical antipsychotics underscore the challenges health care providers face in appropriately treating patients with dementia-related psychosis, including hallucinations and delusions,” said
Details of the posters presented are as follows:
Poster: Treatment Emergent Adverse Events and Associated Adverse Event-Specific Per-Patient-Per-Year Costs: Analysis of Medicare Beneficiaries Treated with Off-Label Atypical Antipsychotics for Dementia-Related Psychosis: Data from a Medicare claims analysis of 23,267 patients with dementia-related psychosis initiating atypical antipsychotic monotherapy from
Poster: Incremental Cost of
Poster: Incremental Cost of Suboptimal Treatment Outcomes Among Patients with Dementia-Related Psychosis: Analysis of Medicare Beneficiaries: An analysis of Medicare claims of 35,100 atypical antipsychotic new start patients with DRP found that nearly two out of three patients experienced at least one suboptimal treatment outcomes (e.g., treatment augmentation, discontinuation or psychosis-specific hospitalizations). Median annual total costs were nearly two times higher (
About Dementia-Related Psychosis
Approximately 8 million people in
It is estimated that 2.4 million Americans (or 30% of people with dementia) experience dementia-related hallucinations and delusions.2,3 These symptoms may be frequent and severe and may recur over time. A hallucination is defined as a perception-like experience that occurs without an external stimulus and is sensory (seen, heard, felt, tasted, sensed) in nature. A delusion is defined as a false, fixed belief that is resolutely held despite evidence to the contrary. Dementia-related psychosis occurs in many types of dementia, including Alzheimer’s disease, dementia with Lewy bodies, Parkinson’s disease dementia, vascular dementia, and frontotemporal dementia. Serious consequences have been associated with psychosis in patients with dementia, such as repeated hospital admissions, increased likelihood of nursing home placement, faster progression of dementia, and increased risk of morbidity and mortality.4
Acadia is trailblazing breakthroughs in neuroscience to elevate life. For more than 25 years we have been working at the forefront of healthcare to bring vital solutions to people who need them most. We developed and commercialized the first and only approved therapy for hallucinations and delusions associated with Parkinson’s disease psychosis. Our late-stage development efforts are focused on dementia-related psychosis, negative symptoms of schizophrenia and Rett syndrome, and in early-stage clinical research we are exploring novel approaches to pain management, and cognition and neuropsychiatric symptoms in central nervous system disorders. For more information, visit us at www.acadia-pharm.com and follow us on LinkedIn and Twitter.
Statements in this press release that are not strictly historical in nature are forward-looking statements. These statements include but are not limited to statements regarding the timing of future events. These statements are only predictions based on current information and expectations and involve a number of risks and uncertainties. Actual events or results may differ materially from those projected in any of such statements due to various factors, including the risks and uncertainties inherent in drug development, approval and commercialization. For a discussion of these and other factors, please refer to Acadia’s annual report on Form 10-K for the year ended
2Plassman BL, et al. Prevalence of dementia in
32017 Alzheimer’s Disease Facts and Figures and Acadia market research.
4Connors MH et al. Am J Geriatr Psychiatry 2018;26(3). Peters ME et al. Am J Psychiatry 2015;172(5). Haupt M et al. Int J Geriatr Psychiatry 1996;11(11). Naimark D et al. J Am Geriatr Soc 1996;44(3). Stern Y et al. Neurology 1994;44(12).