May 31st, 2022 Translational Sciences

Senior Director Translational Medicine

Princeton, New Jersey, United States

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Please be aware that Acadia has a mandatory COVID-19 vaccination policy for all employees.

Position Summary:

Responsibilities include the management of the early development portfolio assets, as well as the assessment of licensing opportunities and assessment of their compatibility with the existing portfolio. The role involves developing and delivering clinical strategy plans across multiple disease areas in neuroscience. Provides strategy to progress compounds up to proof-of-concept growing their probability of success through the use of innovative target engagement and pharmacodynamics read-outs. Provides critical input on positioning compounds in their efficient indications based on the target knowledge, preclinical data, and early human evidence.

Primary Responsibilities:

  • Establish strategic clinical development plans and participate with senior management organization strategies
  • Develop and implement study designs and protocol development for phase I and phase II studies
  • Assume medical monitor responsibilities for translational medicine studies
  • Provides recommendations as an SME for due diligences
  • Provides critical thinking around compound positioning, life cycle management, and portfolio strategy


  • Minimum of an MD, equivalent education, and experience may be considered
  • Additional degree in basic sciences is a plus (MSc, Ph.D.)
  • Minimum of 10 years of hands-on experience in Clinical Pharmacology, Experimental Medicine, and Translational Research in CNS disorders including a minimum of 5 years in a leadership role.
  • Experience planning and implementing development studies including first-in-human, proof-of-mechanism pharmacodynamic studies, and proof of concept studies
  • Direct experience and responsibilities in regulatory interactions, including IND opening and CTA submissions
  • Experience with diverse phase II study designs
  • Experience in the compound development strategy in multiple psychiatric and neurological indications
  • General knowledge and understanding of clinical pharmacology principles applied to early development studies and biostatistics.
  • Excellent interpersonal communication and networking skills with the ability to build cross-functional bridges.
  • Skilled at negotiating with business partners or management and influencing senior-level leaders regarding matters of significance to the organization
  • Proficient at crafting and communicating a clear vision among team members to align resources and activities to achieve functional area and/or organizational goals.
  • Experience working with commercial organizations (e.g., US and global commercial, early commercial strategy) but not vital


Establishes strategic plans for designated function(s) and participates cross-functionally to align objectives across the organization. Develops methods, techniques, and evaluation criteria for projects, programs, and people. Works on complex issues where analysis of situations or data requires an in-depth knowledge of the functional area and related organizational objectives. Erroneous decisions will have a serious impact on the overall success of the department and may impact the long-term progress of the company.

Physical Requirements:

While performing the duties of this job, the employee is regularly required to stand; walk; sit; use hands to finger, handle, or feel; reach with hands and arms; climb or balance; stoop, kneel, crouch, see, talk or hear in a standard office environment. The employee must occasionally lift and/or move up to 15 pounds.

#LI-Hybrid #LI-MH1


What we offer you:

  • Competitive base, bonus, new hire and ongoing equity packages
  • Medical, dental, and vision insurance
  • 401(k) Plan with a fully vested company match 1:1 up to 5%
  • Employee Stock Purchase Plan with a 2-year purchase price lock-in
  • 15+ vacation days
  • 14 paid holidays plus one floating holiday of your choice, including office closure between December 24th and January 1st
  • 10 days of paid sick time
  • Paid parental leave
  • Tuition assistance

EEO Statement:

Studies have shown that women and people of color are less likely to apply for jobs unless they believe they meet every single one of the qualifications in the exact way they are described in job postings. We are committed to building a diverse, equitable, inclusive, and innovative company and we are looking for the BEST candidate for the job. That candidate may be one who comes from a less traditional background or may meet the qualifications in a different way. We would strongly encourage you to apply – especially if the reason you are the best candidate isn’t exactly as we describe it here.

It is the policy of Acadia to provide equal employment opportunities to all employees and employment applicants without regard to considerations of race, including related to hairstyle, color, religion or religious creed, sexual orientation, gender, gender identity, gender expression, gender transition, country of origin, ancestry, citizenship, age, physical or mental disability, genetic information, legally-protected medical condition or information, marital status, domestic partner status, family care status, military caregiver status, veteran or military status (including reserve status, National Guard status, and military service or obligation), status as a victim of domestic violence, sexual assault or stalking, enrollment in a public assistance program, or any basis protected under federal, state or local law.

As an equal opportunity employer, Acadia is committed to a diverse workforce. If you are a qualified individual with a disability or a disabled veteran, you have the right to request a reasonable accommodation. Furthermore, you may request additional support if you are unable or limited in your ability to use or access Acadia’s career website due to your disability, along with any accommodations throughout the interview process. To request or inquire about your reasonable accommodation, please complete our Reasonable Accommodation Request Form or contact us at [email protected] or 858-261-2923.

Please note that reasonable accommodations granted throughout the recruiting process are not guaranteed to be the same accommodation given if hired. A new request will need to be submitted for any ADA accommodations after starting employment.